WebOct 21, 2013 · Ultrastructural viewing by TEM revealed that these electron-dense tubules emanate from autolysosomes, and possess numerous varicosities at regularly spaced … WebJul 2, 2015 · This tubulation requires mTOR activity, and we identified two direct mTOR phosphorylation sites on UVRAG (S550 and S571) that activate VPS34. Loss of these …
mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation
WebJul 2, 2015 · Lysosomes also act as signalling platforms in activating the nutrient-sensing kinase mTOR. mTOR regulates cellular growth, but it also helps to maintain lysosome identity by initiating lysosomal ... WebOct 18, 2024 · As a multistage process, autophagy comprises initiation, membrane nucleation, membrane growth and extension, autophagosome maturation, and … can ci pin free watch
Kinesin 1 Drives Autolysosome Tubulation: Developmental Cell
WebMar 3, 2024 · Lysosomes serve as degradation hubs for the turnover of endocytic and autophagic cargos, which is essential for neuron function and survival. Deficits in lysosome function result in progressive neurodegeneration in most lysosomal storage disorders and contribute to the pathogenesis of aging-related neurodegenerative diseases. WebMay 1, 2016 · Autophagic lysosome reformation (ALR) plays an important role in maintaining lysosome homeostasis. During ALR, lysosomes are reformed by recycling … fish link bracelet