The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL-2, IL-3, GM-CSF and EPO in hematopoietic ce… WebSep 1, 2024 · NK-cell antitumor function is dependent on the cytokine IL15. Ablation of the IL15 signaling inhibitor CIS ( Cish) enhances NK-cell antitumor immunity by increasing NK-cell metabolism and persistence within the tumor microenvironment (TME).
Investigating cancer drug toxicity leads to a critical discovery
WebMay 4, 2024 · PI3Kδ inhibitors are new to the cancer immunotherapy scene, but they hold promise for their ability to inhibit "regulatory" T cells (Tregs). Tregs normally try to stop other T cells, called... Web1 day ago · Introduction. Nasopharyngeal carcinoma (NPC), a cancer that frequently shows high sensitivity to radio- and chemotherapy, is endemic in Southern China, … imu the globe
CiShh... Nature Reviews Immunology
WebNov 29, 2024 · Cytokine-inducible SH2-containing protein (CIS) is a critical negative regulator of IL-15 signaling in natural killer (NK) cells and is encoded by CISH gene in … WebIn conclusion, Palmer et al. identified a novel role for Cish in immune regulation, and provided sufficient evidence supporting Cish as an … WebAug 25, 2024 · Cytokine inducible SH2-containing protein (CISH) is a natural killer (NK) cell negative regulator of cytokine signaling pathway. To further understand CISH functions … in da hood script