WebThe use of citrullinated Histone H3 (Cit-H3) as an early sepsis marker and outcome predictor has been validated in previous studies among adults. However, only one study in pediatric meningococcal sepsis was reported with contradictory results. This study aims to determine Cit-H3 levels in pediatric clinical sepsis and analyze its association ... WebMay 5, 2024 · National Center for Biotechnology Information
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WebNeutralization of Cit H3 significantly improves survival in septic mice. Collectively, our findings indicate for the first time that Cit H3 could not only serve as a potential … WebIn experiment III, administration of LPS (LD) caused a rise in serum H3 and Cit H3 but not Ac H3 at 3 hours, and all of these animals died within 23 hours (100% mortality). Decreasing the dose of LPS (SD) significantly reduced the mortality rate (10% mortality) as well as the circulating levels of Cit H3 (non detectable) and H3. irspayment.gov
CitH3: a reliable blood biomarker for diagnosis and treatment of ...
Web总组蛋白H3定量试剂盒-瓜氨酸化 (Citrullination)修饰. 摘要. 随着科研的深入,认识到有些免疫学疾病发病机制可能与组蛋白H3的瓜氨酸化的变化有关。. 因此,总组蛋白H3瓜氨酸 … WebIn this study, we investigated whether citrullinated histone H3 (H3Cit) could serve as a biomarker for the detection of critical liver damage in sepsis and the efficacy of … WebFeb 16, 2024 · To identify signs of NETosis in the ischemic brain, we used different antibodies against neutrophil (NIMP-R14), elastase and citrulline histone 3 (Cit-H3). Our data show that early administration of DNase-I significantly reduces the presence of neutrophils with Cit-H3 and neutrophil elastase positive staining in the ischemic cortex … portal intelisys ca