WebHowever, similar to the action of ARNT in response to hypoxic cellular conditions, ARNT2 does exhibit the ability to interact with HIF-1α and induce hypoxia element-driven gene expression (Sekine et al. 2006), suggesting that this protein is functionally more important in HIF-1α-mediated signaling than in AHR-mediated signaling. Web21 de mar. de 2024 · Size: 826 amino acids Molecular mass: 92670 Da Protein existence level: PE1 Quaternary structure: Interacts with the ARNT; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:10944113, 20699359). Interacts with COPS5; the interaction …
Regulatory mechanism of HIF-1α and its role in liver diseases: a ...
WebA Per-Arnt-Sim (PAS) domain is a protein domain found in all kingdoms of life. Generally, the PAS domain acts as a molecular sensor, whereby small molecules and other proteins associate via binding of the PAS domain. Due to this sensing capability, the PAS domain has been shown as the key structural motif involved in protein-protein interactions of the … Web20 de nov. de 2011 · Similar changes were observed after knockdown of the HIF-α dimerization partner ARNT (aryl hydrocarbon receptor nuclear translocator) in VHL-deficient normoxic UMRC2 cells, which express both HIF ... boyne splash mountain
Hypoxia-Inducible Aryl Hydrocarbon Receptor Nuclear …
Web13 de mai. de 2014 · The aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as hypoxia-inducible factor (HIF)-1β, plays a pivotal role in the adaptive … Web結構. 缺氧大部分需要氧氣呼吸的物種，都擁有保守序列HIF-1。 其轉錄都有嚴格的調控機制。HIF-1是由一個α亞基和一個β亞基組成的異源蛋白二聚體，而β亞基是一種 芳香烃受体核转位子 （ 英语 ： Aryl hydrocarbon receptor nuclear translocator ） （ARNT） 。 HIF-1屬於鹼性螺旋-環-螺旋（bHLH）家族中的PER-ARNT-SIM ... Web8 de out. de 2024 · 随后，他们又进一步明确了hif的蛋白结构：hif主要由两种结合不同dna位点的蛋白组成，分别为hif-1α和arnt。一旦氧气浓度下降，hif-1α的含量开始上升，这样大量的hif-1α就能结合到epo基因附近来调节epo的表达。并且，hif-1α在正常情况下会迅速降解，以保证氧气 ... boyne street alliston