Webb28 mars 2024 · Encoded by the MEN1 gene, menin protein is a fusion protein that is essential for the oncogenic transformation of mixed-lineage leukemia (MLL) and leads to acute leukemia (AL). Therefore, accumulating evidence has demonstrated that inhibition of the high-affinity relationship between menin and mixed-lineage leukemia 1 (MLL1 and … WebbDevelopment of p62-Keap1 protein–protein interaction inhibitors as doxorubicin-sensitizers against non-small cell lung cancer ... K67 and KOA153 that overcome chemotherapy resistance in human hepatocellular carcinoma cell lines by inhibiting the protein–protein interactions between p62 and Kelch-like ECH ...
Peptide-based Inhibitors of Protein-Protein Interactions of Src ...
Webb1 dec. 2013 · Protein–protein interaction (PPI) interfaces are considered desirable targets for drug companies that are focused on discovering highly selective inhibitors while … Webb18 sep. 2014 · Inhibitor of apoptosis proteins (IAPs), including cIAP1, cIAP2, and XIAP, are important regulators of cell fate, including apoptotic cell death and immunity (Dubrez et al., 2013, Fulda and Vucic, 2012). The IAPs have PPI interaction domains called BIR domains and a RING domain E3 ubiquitin-ligase domain. can eggs give dogs diarrhea
Developing Small-Molecule Inhibitors of Protein-Protein …
Webbβ-Strand mediated protein–protein interactions (PPIs) represent underexploited targets for chemical probe development despite representing a significant proportion of known and therapeutically relevant PPI targets. β-Strand mimicry is challenging given that both amino acid side-chains and backbone hydrogen-bonds are typically required for … Webb28 mars 2024 · Encoded by the MEN1 gene, menin protein is a fusion protein that is essential for the oncogenic transformation of mixed-lineage leukemia (MLL) and leads … Webb25 jan. 2024 · The RAS gene family is frequently mutated in human cancers, and the quest for compounds that bind to mutant RAS remains a major goal, as it also does for inhibitors of protein–protein interactions. We have refined crystallization conditions for KRAS 169 Q61H-yielding crystals suitable for soaking with compounds and exploited this to … fis project manager