Oocyte meiotic spindle assembly and function
Web6 de set. de 2024 · Cullin ring-finger ubiquitin ligase 4 (CRL4) has multiple functions in the maintenance of oocyte survival and meiotic cell cycle progression. DCAF13, a novel CRL4 adaptor, is essential for oocyte development. But the mechanisms by which CRL4-DCAF13 supports meiotic maturation remained unclear. In this study, we demonstrated that … WebOocyte Meiotic Spindle Assembly and Function Aaron F. Severson1, George von Dassow2, and Bruce Bowerman3,4 1 Center for Gene Regulation in Health and Disease; …
Oocyte meiotic spindle assembly and function
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Web20 de dez. de 2024 · Background ADD1 (adducin-1) and TPX2 (targeting protein for Xklp2) are centrosomal proteins and regulate mitotic spindle assembly. Mammalian oocytes that segregate homologous chromosomes in Meiosis I and sister chromatids in Meiosis II with a spindle lacking centrosomes are more prone to chromosome segregation errors than in … Web10 de mai. de 2011 · Here, we report Ndc80 expression, localization, and possible functions in mouse oocyte meiosis. Ndc80 mRNA levels gradually increased during meiosis. Immunofluorescent staining showed that Ndc80 was restricted to the germinal vesicle and associated with spindle microtubules from the Pro-MI to MII stages.
Web15 de jul. de 2024 · Here, porcine oocytes were selected to reveal the spatiotemporal and function of TPX2 in microtubule spindle assembly during meiotic maturation. Furthermore, these results will help to further extend an understanding of the potential etiology of porcine oocyte maturation defects. Section snippets Ethics statement Web22 de nov. de 2024 · Actin takes over various essential function during oocyte meiosis, many of which commonly rely on microtubules in mitotic cells. Specifically, the actin network has been linked to long-range vesicle transport, nuclear positioning, spindle migration and anchorage, polar body extrusion and accurate chromosome segregation in mammalian …
WebHere, we review four aspects of meiosis I that are significantly affected by the absence of centrosomes in oocyte spindles. One, microtubules tend to assemble around the … Web23 de jul. de 2024 · Meiosis in female oocytes lacks centrosomes, the microtubule-organizing centers. In Drosophila oocytes, meiotic spindle assembly depends on the chromosomal passenger complex (CPC). To investigate the mechanisms that regulate Aurora B activity, we examined the role of protein phosphatase 2A (PP2A) in Drosophila …
Web11 de out. de 2024 · Our data support a model of actin-microtubule interplay that is essential for bipolar spindle assembly and correct partitioning of the nuclear genome in human oocyte meiosis. Oocytes prepare...
Web25 de fev. de 2024 · Since its recent discovery [ 45 ], several studies have indicated a role of the complex in key processes buttressing oocyte to embryo transition, including meiotic spindle formation and positioning, regulation of translation, organelle redistribution, and epigenetic reprogramming (reviewed in [ 46 ]). dana buchman sleeveless tops 1x2xWeb10 de abr. de 2024 · Importantly, clustering of chromosomes is a prerequisite to their correct and complete capture by the meiotic spindle ( Figure 1 B). This work adds to a growing … birds as art websiteWeb6 de out. de 2024 · To this end, the oocyte eliminates half of its chromosomes into a small cell termed a polar body. The egg is then released into the Fallopian tube, where … birds as house petsWeb10 de abr. de 2024 · In starfish oocytes, actin drives chromosome clustering after NEBD 2,3. In mouse oocytes, a Formin-2/Spire-nucleated actin network is responsible for spindle … birds as a tool in environmental monitoringWebHá 1 hora · Left indicates representative oocyte with zero univalents. Right indicates representative oocyte with ... him-3 R93Y and htp-1 G97T mutants have functional … dana buchman sleeveless topsWebTo this end, the oocyte eliminates half of its chromosomes into a small cell termed a polar body. The egg is then released into the Fallopian tube, where it can be fertilized. Upon … dana buchman tall boots brownWebWe show that KLP-7, the single mitotic centromere-associated kinesin (MCAK)/kinesin-13 in Caenorhabditis elegans, is required for bipolar … birds article