WebFeb 2, 2024 · In terms of pathological conditions, premature ovarian insufficiency (POI) is a common reproductive disorder characterized by menstrual disturbances with elevated gonadotrophin levels and decreased estradiol levels before the age of 40 years, and POI affects 1–5% of women [ 4 ]. WebNov 22, 2024 · Activated mTOR complex 1 (mTORC1) acts on several downstream targets including ribosomal protein S6 (RPS6) kinase (RPS6K) and mRNA translation proteins like eukaryotic translation initiation factor 4 (eIF4) and eukaryotic translation elongation factor 2, thereby resulting in increased mRNA translation, ribosome biogenesis, and protein …
Ribosomal Protein S6: A Potential Therapeutic Target …
WebrpS6 (CST, Danvers, MA, USA, 1:25), cleaved Cas-pase-3 (CST, 1:400), p53 protein (Abcam, Cambridge, UK, 1:100), Cytochrome c (CST, 1:100), and GFP (Nacalai Tesque, Kyoto, Japan, 1:100). They were incubated overnight at 4°C and washed three times for 3 min each in PBT, followed by incubation at room temperature for 1 h with secondary antibodies ... WebNov 27, 2024 · In this study, we discovered that the TOR-S6K-RPS6 pathway contributes to the light-triggered translation enhancement in deetiolating Arabidopsis seedlings before they acquire photosynthetic activities. The TOR-S6K-RPS6 pathway can be triggered by far-red and blue light photoreceptors but is repressed by a key negative regulator COP1 in the dark. bts fg tシャツ
Ribosomal Protein S6 - an overview ScienceDirect Topics
WebPhospho-S6 Ribosomal Protein (Ser235/236) Antibody detects endogenous levels of ribosomal protein S6 only when phosphorylated at serine 235 … WebRPS6 is an important protein constituent of the 40S small subunit, located in the mRNA binding site of cytosolic ribosomes, and is the first ribosome protein dis- covered to undergo phosphorylation [9]. RPS6 has import- ant functions in tumorigenesis and development. WebDec 6, 2024 · Phosphorylation of Ribosomal Protein S6 (RPS6) was the first post-translational modification of the ribosome to be identified and is a commonly-used … expand 2 x 7 3 x 1